Publications

  • Binh Tran TD, Hernandez CM, Nguyen H, Wright S, Center for Systems Neurogenetics of Addiction, Tarantino LM, Chesler EJ, Weinstock GM, Zhou Y, Bubier JA. The microbial community dynamics of cocaine sensitization in two behaviorally divergent strains of Collaborative Cross mice. Genes, Brain and Behavior. 27 April 2023. https://doi.org/10.1111/gbb.12845

  • Binh Tran TD, Nguyen H, Sodergren E, Addiction CFSNO, Dickson PE, Wright SN, Philip VM, Weinstock GM, Chesler EJ, Zhou Y, Bubier JA. Microbial glutamate metabolism predicts intravenous cocaine self-administration in diversity outbred mice. Neuropharmacology. 2023 March 15;226:109409. PubMed PMID: 36592885; PubMed Central PMCID: PMC9943525; DOI: 10.1016/j.neuropharm.2022. 109409.
  • Bailey LS, Bagley JR, Wherry JD, Chesler EJ, Karkhanis A, Jentsch JD, Tarantino LM. Repeated dosing with cocaine produces strain-dependent effects on responding for conditioned reinforcement in Collaborative Cross mice. Psychopharmatology. 2023 March:240(3):561-573. PubMed PMID: 36239767; DOI: 10.1007/s00213-022-06256-9.
  • Bagley JR, Bailey LS, Gagnon LH, He H, Philip VM, Reinholdt LG, Tarantino LM, Chesler EJ, Jentsch JD. Behavioral phenotypes revealed during reversal learning are linked with novel genetic loci in diversity outbred mice. Addiction Neuroscience. 2022 December 4. PubMed PMID: 36714272; PubMed Central PMDIC: PMC9879139; DOI: 10.1016/j.addicn.2022.100045.
  • Bagley JR, Khan AH, Smith DJ, Jentsch JD. Extreme phenotypic diversity in operant response to intravenous cocaine or saline infusion in the hybrid mouse diversity panel. Addict Biol. 2022 May;27(3):e13162. doi: 10.1111/adb.13162. PMID: 35470554
  • Gaines CH, Schoenrock SA, Farrington J, Lee DF, Aponte-Collazo LJ, Shaw GD, Miller DR, Ferris MT, Pardo-Manuel de Villena F, Tarantino LM. Cocaine-Induced Locomotor Activation Differs Across Inbred Mouse Substrains. Front Psychiatry. 2022 May 6;13:800245. doi: 10.3389/fpsyt.2022.800245. PMID: 35599758; PMCID: PMC9120424.
  • Bagley JR, Kashinsky WM, Jentsch JD. A system for continuous and automated measurement of mouse home-cage drinking with automated control of liquid access. bioRxiv 2021.02.10.430693; doi: https://doi.org/10.1101/2021.02.10.430693
  • Huggett SB, Johnson EC, Hatoum AS, Lai D, Bubier JA, Chesler EJ, Agrawal A, Palmer AA, Edenberg HJ, Palmer RHC. Genes identified in rodent studies of alcohol intake are enriched for heritability of human substance use. Alcoholism, Clinical and Experimental Research. 2021 December;45(12)2485-2494. PubMed PMID: 34751961; PubMed Central PMCID: PMC9714312; DOI:10.1111/acer.14738.
  • DePoy LM, Becker-Krail DD, Zhong W, Shah N, Brandon JH, Miguelino AM, Tseng GC, Logan RW, McClung CA. Circadian-and sex-dependent increases in intravenous cocaine self-administration in Npas2 mutant mice. The Journal of neuroscience: the official journal of the Society for Neuroscience. Forthcoming.
  • Bailey LS, Bagley JR, Dodd R, Olson A, Bolduc M, Philip VM, Reinholdt LG, Sukoff Rizzo SJ, Tarantino L, Gagnon L, Chesler EJ, Jentsch JD. Heritable variation in locomotion, reward sensitivity and impulsive behaviors in a genetically diverse inbred mouse panel. Genes Brain Behav. 2021 Nov;20(8):e12773. doi: 10.1111/gbb.12773. Epub 2021 Oct 21. PubMed PMID: 34672075.
  • Moore A, Linden J, Jentsch JD. Syn3 Gene Knockout Negatively Impacts Aspects of Reversal Learning Performance. eNeuro. 2021 Sep-Oct;8(5). doi: 10.1523/ENEURO.0251-21.2021. Print 2021 Sep-Oct. PubMed PMID: 34413083; PubMed Central PMCID: PMC8431823.
  • Parker CC, Philip VM, Gatti DM, Kasparek S, Kreuzman AM, Kuffler L, Mansky B, Masneuf S, Sharif K, Sluys E, Taterra D, Taylor WM, Thomas M, Polesskaya O, Palmer AA, Holmes A, Chesler EJ. Genome-wide association mapping of ethanol sensitivity in the Diversity Outbred mouse population. [preprint]. 2021 September. Available from: https://www.biorxiv.org/content/10.1101/2021.09.06.459155v1.
  • Sun KY, Oreper D, Schoenrock SA, McMullan R, Giusti-Rodríguez P, Zhabotynsky V, Miller DR, Tarantino LM, Pardo-Manuel de Villena F, Valdar W. Bayesian modeling of skewed X inactivation in genetically diverse mice identifies a novel Xce allele associated with copy number changes. Genetics. 2021 May 17;218(1). doi: 10.1093/genetics/iyab034. PubMed PMID: 33693696; PubMed Central PMCID: PMC8128399.
  • Bagley JR, Chesler EJ, Philip VM, Jentsch JD. Heritability of ethanol consumption and pharmacokinetics in a genetically diverse panel of collaborative cross mouse strains and their inbred founders. Alcohol Clin Exp Res. 2021 Apr;45(4):697-708. doi: 10.1111/acer.14582. Epub 2021 Apr 7. PubMed PMID: 33619752; PubMed Central PMCID: PMC8441258.
  • Buck SA, Torregrossa MM, Logan RW, Freyberg Z. Roles of dopamine and glutamate co-release in the nucleus accumbens in mediating the actions of drugs of abuse. FEBS J. 2021 Mar;288(5):1462-1474. doi: 10.1111/febs.15496. Epub 2020 Aug 11. Review. PubMed PMID: 32702182; PubMed Central PMCID: PMC7854787.
  • Huggett SB, Bubier JA, Chesler EJ, Palmer RHC. Do gene expression findings from mouse models of cocaine use recapitulate human cocaine use disorder in reward circuitry? Genes Brain Behav. 2021 Feb;20(2):e12689. doi: 10.1111/gbb.12689. Epub 2020 Sep 15. PubMed PMID: 32720468; PubMed Central PMCID: PMC8173322.
  • Kim SM, Vadnie CA, Philip VM, Gagnon LH, Chowdari KV, Chesler EJ, McClung CA, Logan RW. High-throughput measurement of fibroblast rhythms reveals genetic heritability of circadian phenotypes in diversity outbred mice and their founder strains. Sci Rep. 2021 Jan 28;11(1):2573. doi: 10.1038/s41598- 021-82069-8. PubMed PMID: 33510298; PubMed Central PMCID: PMC7843998.
  • Ketchesin KD, Zong W, Hildebrand MA, Seney ML, Cahill KM, Scott MR, Shankar VG, Glausier JR, Lewis DA, Tseng GC, McClung CA. Diurnal rhythms across the human dorsal and ventral striatum. Proc Natl Acad Sci U S A. 2021 Jan 12;118(2). doi: 10.1073/pnas.2016150118. PubMed PMID: 33372142; PubMed Central PMCID: PMC7812799.
  • Seney ML, Logan RW. Critical roles for developmental hormones and genetic sex in stress-induced transcriptional changes associated with depression. Neuropsychopharmacology. 2021 Jan;46(1):221-222. doi: 10.1038/s41386-020-00792-8. PubMed PMID: 32770141; PubMed Central PMCID: PMC7689456
  • Reynolds T, Johnson EC, Huggett SB, Bubier JA, Palmer RHC, Agrawal A, Baker EJ, Chesler EJ. Interpretation of psychiatric genome-wide association studies with multispecies heterogeneous functional genomic data integration. Neuropsychopharmacology. 2021 Jan;46(1):86-97. doi: 10.1038/s41386-020- 00795-5. Epub 2020 Aug 13. Review. PubMed PMID: 32791514; PubMed Central PMCID: PMC7688940.
  • Skelly DA, Czechanski A, Byers C, Aydin S, Spruce C, Olivier C, Choi K, Gatti DM, Raghupathy N, Keele GR, Stanton A, Vincent M, Dion S, Greenstein I, Pankratz M, Porter DK, Martin W, O’Connor C, Qin W, Harrill AH, Choi T, Churchill GA, Munger SC, Baker CL, Reinholdt LG. Mapping the Effects of Genetic Variation on Chromatin State and Gene Expression Reveals Loci That Control Ground State Pluripotency. Cell Stem Cell. 2020 Sep 3;27(3):459-469.e8. doi: 10.1016/j.stem.2020.07.005. Epub 2020 Aug 13. PubMed PMID: 32795400; PubMed Central PMCID: PMC7484384.
  • Bubier JA, He H, Philip VM, Roy T, Hernandez CM, Bernat R, Donohue KD, O”Hara BF, Chesler EJ. Genetic variation regulates opioid-induced respiratory depression in mice. Scientific Reports. 2020 September; 10(1):14970. doi: 10.1038/s41598-020-71804-2.
  • Ouellette AR, Neuner SM, Dumitrescu L, Anderson LC, Gatti DM, Mahoney ER, Bubier JA, Churchill G, Peters L, Huentelman MJ, Herskowitz JH, Yang HS, Smith AN, Reitz C, Kunkle BW, White CC, De Jager PL, Schneider JA, Bennett DA, Seyfried NT, Chesler EJ, Hadad N, Hohman TJ, Kaczorowski CC. Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer’s Dementia. Cell Rep. 2020 Sep 1;32(9):108091. doi: 10.1016/j.celrep.2020.108091. PubMed PMID: 32877673; PubMed Central PMCID: PMC7502175.
  • Bubier JA, Philip VM, Dickson PE, Mittleman G, Chesler EJ. Discovery of a Role for Rab3b in Habituation and Cocaine Induced Locomotor Activation in Mice Using Heterogeneous Functional Genomic Analysis. Front Neurosci. 2020;14:721. doi: 10.3389/fnins.2020.00721. eCollection 2020. PubMed PMID: 32742255; PubMed Central PMCID: PMC7364128.
  • Maroni MJ, Capri KM, Arruda NL, Gelineau RR, Deane HV, Concepcion HA, DeCourcey H, Monteiro De Pina IK, Cushman AV, Chasse MH, Logan RW, Seggio JA. Substrain specific behavioral responses in male C57BL/6N and C57BL/6J mice to a shortened 21-hour day and high-fat diet. Chronobiol Int. 2020 Jun;37(6):809-823. doi: 10.1080/07420528.2020.1756840. Epub 2020 May 13. PubMed PMID: 32400203; PubMed Central PMCID: PMC7758871.
  • Schoenrock SA, Kumar P, Gómez-A A, Dickson PE, Kim SM, Bailey L, Neira S, Riker KD, Farrington J, Gaines CH, Khan S, Wilcox TD, Roy TA, Leonardo MR, Olson AA, Gagnon LH, Philip VM, Valdar W, de Villena FP, Jentsch JD, Logan RW, McClung CA, Robinson DL, Chesler EJ, Tarantino LM. Characterization of genetically complex Collaborative Cross mouse strains that model divergent locomotor activating and reinforcing properties of cocaine. Psychopharmacology (Berl). 2020 Apr;237(4):979-996. doi: 10.1007/s00213-019-05429-3. Epub 2020 Jan 3. PubMed PMID: 31897574; PubMed Central PMCID: PMC7542678.
  • Datta U, Schoenrock SE, Bubier JA, Bogue MA, Jentsch JD, Logan RW, Tarantino LM, Chesler EJ. Prospects for finding the mechanisms of sex differences in addiction with human and model organism genetic analysis. Genes Brain Behav. 2020 Mar;19(3):e12645. doi: 10.1111/gbb.12645. Epub 2020 Feb 11. Review. PubMed PMID: 32012419; PubMed Central PMCID: PMC7060801
  • Bubier JA, Philip VM, Quince C, Campbell J, Zhou Y, Vishnivetskaya T, Duvvuru S, Blair RH, Ndukum J, Donohue KD, Foster CM, Mellert DJ, Weinstock G, Culiat CT, O’Hara BF, Palumbo AV, Podar M, Chesler EJ. A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice. Genetics. 2020 Mar;214(3):719-733. doi: 10.1534/genetics.119.303013. Epub 2020 Jan 2. PubMed PMID: 31896565; PubMed Central PMCID: PMC7054020.
  • Huggett SB. Meso-limbic Gene Expression Findings from Mouse Cocaine Self-Administration Recapitulate Human Cocaine Use Disorder. [preprint]. 2020 February. doi: 2020.01.31.929406
  • Mitra A, Deats SP, Dickson PE, Zhu J, Gardin J, Nieman BJ, Henkelman RM, Tsai N, Chesler EJ, Zhang Z, Kumar V. Tmod2 is a regulator of cocaine responses through control of striatal and cortical excitability, and drug-induced plasticity. [preprint]. 2020 February. doi: 648295.
  • Saul M, Jentsch D, Logan R, McClung C, Philip V, Reinholdt L, Tarantino L, Chesler E, Bagley J, Bailey L, Datta U, Dickson P, Dodd R, Gagnon L, Kimble V, Leonardo M, Kim S, Olson A, Roy T, Schoenrock S, Wilcox T, Rizzo S. Genetic variation and sex differences are missed opportunities for addiction biology. [preprint]. 2020 February. Available from: https://doi.org/10.1101/2020.02.14.949784.
  • Paden W, Barko K, Puralewski R, Cahill KM, Huo Z, Shelton MA, Tseng GC, Logan RW, Seney ML. Sex differences in adult mood and in stress-induced transcriptional coherence across mesocorticolimbic circuitry. Transl Psychiatry. 2020 Feb 6;10(1):59. doi: 10.1038/s41398-020-0742-9. PubMed PMID: 32066699; PubMed Central PMCID: PMC7026087.
  • Mitra A, Deats SP, Dickson PE, Zhu J, Gardin J, Nieman BJ, Henkelman RM, Tsai N, Chesler EJ, Zhang Z, Kumar V. Tmod2 is a regulator of cocaine responses through control of striatal and cortical excitability, and drug-induced plasticity. bioRxiv. 2020 February.
  • Capri KM, Maroni MJ, Deane HV, Concepcion HA, DeCourcey H, Logan RW, Seggio JA. Male C57BL6/N and C57BL6/J Mice Respond Differently to Constant Light and Running-Wheel Access. Front Behav Neurosci. 2019;13:268. doi: 10.3389/fnbeh.2019.00268. eCollection 2019. PubMed PMID: 31920578; PubMed Central PMCID: PMC6914853.
  • Calvo M, Davies AJ, Hébert HL, Weir GA, Chesler EJ, Finnerup NB, Levitt RC, Smith BH, Neely GG, Costigan M, Bennett DL. The Genetics of Neuropathic Pain from Model Organisms to Clinical Application. Neuron. 2019 Nov 20;104(4):637-653. doi: 10.1016/j.neuron.2019.09.018. Review. PubMed PMID: 31751545; PubMed Central PMCID: PMC6868508.
  • Recla JM, Bubier JA, Gatti DM, Ryan JL, Long KH, Robledo RF, Glidden NC, Hou G, Churchill GA, Maser RS, Zhang ZW, Young EE, Chesler EJ, Bult CJ. Genetic mapping in Diversity Outbred mice identifies a Trpa1 variant influencing late-phase formalin response. Pain. 2019 Aug;160(8):1740-1753. doi: 10.1097/j.pain.0000000000001571. PubMed PMID: 31335644; PubMed Central PMCID: PMC6668363.
  • Boehm FJ, Chesler EJ, Yandell BS, Broman KW. Testing Pleiotropy vs. Separate QTL in Multiparental Populations. G3 (Bethesda). 2019 Jul 9;9(7):2317-2324. doi: 10.1534/g3.119.400098. PubMed PMID: 31092608; PubMed Central PMCID: PMC6643884.
  • Saul MC, Philip VM, Reinholdt LG, Chesler EJ. High-Diversity Mouse Populations for Complex Traits. Trends Genet. 2019 Jul;35(7):501-514. doi: 10.1016/j.tig.2019.04.003. Epub 2019 May 24. Review. PubMed PMID: 31133439; PubMed Central PMCID: PMC6571031.
  • Skelly DA, Raghupathy N, Robledo RF, Graber JH, Chesler EJ. Reference Trait Analysis Reveals Correlations Between Gene Expression and Quantitative Traits in Disjoint Samples. Genetics. 2019 Jul;212(3):919-929. doi: 10.1534/genetics.118.301865. Epub 2019 May 21. PubMed PMID: 31113812; PubMed Central PMCID: PMC6614885.
  • Cates HM, Benca-Bachman CE, de Guglielmo G, Schoenrock SA, Shu C, Kallupi M. National Institute on Drug Abuse genomics consortium white paper: Coordinating efforts between human and animal addiction studies. Genes Brain Behav. 2019 Jul;18(6):e12577. doi: 10.1111/gbb.12577. Epub 2019 May 17. Review. PubMed PMID: 31012252; PubMed Central PMCID: PMC7891887.
  • Parekh PK, Logan RW, Ketchesin KD, Becker-Krail D, Shelton MA, Hildebrand MA, Barko K, Huang YH, McClung CA. Cell-Type-Specific Regulation of Nucleus Accumbens Synaptic Plasticity and Cocaine Reward Sensitivity by the Circadian Protein, NPAS2. J Neurosci. 2019 Jun 12;39(24):4657-4667. doi: 10.1523/JNEUROSCI.2233-18.2019. Epub 2019 Apr 8. PubMed PMID: 30962277; PubMed Central PMCID: PMC6561687.
  • Barko K, Paden W, Cahill KM, Seney ML, Logan RW. Sex-Specific Effects of Stress on Mood-Related Gene Expression. Mol Neuropsychiatry. 2019 Jun;5(3):162-175. doi: 10.1159/000499105. Epub 2019 Apr 30. PubMed PMID: 31312637; PubMed Central PMCID: PMC6597924.
  • Gunduz-Cinar O, Brockway E, Lederle L, Wilcox T, Halladay LR, Ding Y, Oh H, Busch EF, Kaugars K, Flynn S, Limoges A, Bukalo O, MacPherson KP, Masneuf S, Pinard C, Sibille E, Chesler EJ, Holmes A. Identification of a novel gene regulating amygdala-mediated fear extinction. Mol Psychiatry. 2019 Apr;24(4):601-612. doi: 10.1038/s41380-017-0003-3. Epub 2018 Jan 8. PubMed PMID: 29311651; PubMed Central PMCID: PMC6035889.
  • Donvito G, Piscitelli F, Muldoon P, Jackson A, Vitale RM, D’Aniello E, Giordano C, Ignatowska-Jankowska BM, Mustafa MA, Guida F, Petrie GN, Parker L, Smoum R, Sim-Selley L, Maione S, Lichtman AH, Damaj MI, Di Marzo V, Mechoulam R. N-Oleoyl-glycine reduces nicotine reward and withdrawal in mice. Neuropharmacology. 2019 Apr;148:320-331. doi:10.1016/j.neuropharm.2018.03.020. Epub 2018 Mar 19. PubMed PMID: 29567093; PubMed Central PMCID: PMC6408981.
  • Geuther BQ, Deats SP, Fox KJ, Murray SA, Braun RE, White JK, Chesler EJ, Lutz CM, Kumar V. Robust mouse tracking in complex environments using neural networks. Commun Biol. 2019;2:124. doi: 10.1038/s42003-019-0362-1. eCollection 2019. PubMed PMID: 30937403; PubMed Central PMCID: PMC6440983.
  • Dickson PE, Roy TA, McNaughton KA, Wilcox TD, Kumar P, Chesler EJ. Systems genetics of sensation seeking. Genes Brain Behav. 2019 Mar;18(3):e12519. doi: 10.1111/gbb.12519. Epub 2018 Oct 8. PubMed PMID: 30221471; PubMed Central PMCID: PMC6399063.
  • Logan RW, McClung CA. Rhythms of life: circadian disruption and brain disorders across the lifespan. Nat Rev Neurosci. 2019 Jan;20(1):49-65. doi: 10.1038/s41583-018-0088-y. Review. PubMed PMID: 30459365; PubMed Central PMCID: PMC6338075.
  • Tuttle AH, Philip VM, Chesler EJ, Mogil JS. Comparing phenotypic variation between inbred and outbred mice. Nat Methods. 2018 Dec;15(12):994-996. doi: 10.1038/s41592-018-0224-7. PubMed PMID: 30504873; PubMed Central PMCID: PMC6518396.
  • Logan RW, Hasler BP, Forbes EE, Franzen PL, Torregrossa MM, Huang YH, Buysse DJ, Clark DB, McClung CA. Impact of Sleep and Circadian Rhythms on Addiction Vulnerability in Adolescents. Biol Psychiatry. 2018 Jun 15;83(12):987-996. doi: 10.1016/j.biopsych.2017.11.035. Epub 2017 Dec 15. Review. PubMed PMID: 29373120; PubMed Central PMCID: PMC5972052.
  • Yuan JT, Gatti DM, Philip VM, Kasparek S, Kreuzman AM, Mansky B, Sharif K, Taterra D, Taylor WM, Thomas M, Ward JO, Holmes A, Chesler EJ, Parker CC. Genome-wide association for testis weight in the diversity outbred mouse population. Mamm Genome. 2018 Jun;29(5-6):310-324. doi: 10.1007/s00335-018-9745-8. Epub 2018 Apr 24. PubMed PMID: 29691636; PubMed Central PMCID: PMC6396879.
  • Egervari G, Ciccocioppo R, Jentsch JD, Hurd YL. Shaping vulnerability to addiction – the contribution of behavior, neural circuits and molecular mechanisms. Neurosci Biobehav Rev. 2018 Feb;85:117-125. doi: 10.1016/j.neubiorev.2017.05.019. Epub 2017 May 29. Review. PubMed PMID: 28571877; PubMed Central PMCID: PMC5708151.
  • DePoy LM, McClung CA, Logan RW. Neural Mechanisms of Circadian Regulation of Natural and Drug Reward. Neural Plast. 2017;2017:5720842. doi: 10.1155/2017/5720842. Epub 2017 Nov 21. Review. PubMed PMID: 29359051; PubMed Central PMCID: PMC5735684.
  • Delprato A, Algéo MP, Bonheur B, Bubier JA, Lu L, Williams RW, Chesler EJ, Crusio WE. QTL and systems genetics analysis of mouse grooming and behavioral responses to novelty in an open field. Genes Brain Behav. 2017 Nov;16(8):790-799. doi: 10.1111/gbb.12392. Epub 2017 Jun 22. PubMed PMID: 28544613; PubMed Central PMCID: PMC5800503.
  • Parker CC, Dickson PE, Philip VM, Thomas M, Chesler EJ. Systems Genetic Analysis in GeneNetwork.org. Curr Protoc Neurosci. 2017 Apr 10;79:8.39.1-8.39.20. doi: 10.1002/cpns.23. PubMed PMID: 28398643; PubMed Central PMCID: PMC5548442.